Shoshana Levy

Postdoctoral Advisees

Neta Madar, Yael Sagi

Web Site Links

• Personal Web site

Research Interests

Our research focuses on the mechanism of action of tetraspanins, an evolutionary conserved, widely expressed multi-gene family. We study a prototype, CD81, a molecule implicated in the pathogenesis of two major human diseases: hepatitis C virus (HCV) and malaria.

Publications

• Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin. Coffey GP, Rajapaksa R, Liu R, Sharpe O, Kuo CC, Krauss SW, Sagi Y, Davis RE, Staudt LM, Sharman JP, Robinson WH, Levy S. J Cell Sci. 2009; 122 (Pt 17): 3137-44
• Wiskott-Aldrich syndrome protein is an effector of Kit signaling. Mani M, Venkatasubrahmanyam S, Sanyal M, Levy S, Butte A, Weinberg K, Jahn T. Blood. 2009; 114 (14): 2900-8
• Enhanced B cell activation in the absence of CD81. Sanyal M, Fernandez R, Levy S. Int Immunol. 2009; 21 (11): 1225-37
• Generation of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees. Varghese B, Widman A, Do J, Taidi B, Czerwinski DK, Timmerman J, Levy S, Levy R. Blood. 2009
• Cell-free production of Gaussia princeps luciferase - antibody fragment bioconjugates for ex vivo detection of tumor cells. Patel KG, Ng PP, Kuo CC, Levy S, Levy R, Swartz JR. Biochem Biophys Res Commun. 2009