Rajat Rohatgi

Clinical Focus

• Cancer
• Internal Medicine

Honors and Awards

• Josephine Q. Berry Faculty Scholar in Cancer Research, Stanford University (2009)
• Howard Temin Pathway to Independance Award (K99/R00), NCI/NIH (2007)
• Young Investigator Award, American Society for Clinical Oncology (2007)
• Fellowship Award, Damon Runyon Cancer Research Fund (2006)

Professional Education

Research Interests

We are working to elucidate the biochemical and cell biological principles that govern signaling pathways that sit at the intersection between developmental biology and cancer. Our toolkit combines bulk biochemical techniques, such as cell-free reconstitution, with microscopy using novel optical probes to study the dynamics of signal propagation in cells. We strive to develop novel strategies for the manipulation of these pathways for cancer therapies and applications in regenerative medicine.

Publications

• Hedgehog signal transduction by smoothened: pharmacological evidence for a two-step activation process. Rohatgi R, Milenkovic L, Corcoran RB, and Scott MP. Proceedings of the National Academy of Sciences USA. 2009: 106 3196-3201
• Arrestin’ Movement in Cilia. Rohatgi R, Scott MP. Science. 2008; 320 (5884): 1777-1781
• Patched1 regulates Hedgehog signaling at the primary cilium. Rohatgi R, Milenkovic, Scott MP. Science. 2007; 317 (5836): 372-376
• Patching the gaps in Hedgehog signaling. Rohatgi R, Scott MP. Nat Cell Bio. 2007; 9 (9): 1005-1009
• In vitro reconstitution of cdc42-mediated actin assembly using purified components. Ho HY, Rohatgi R, Lebensohn A, Kirschner MW. Methods in Enzymology. 2006: 406 174-190